Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Furthermore, rs4774*C was associated with DRB1*1501+ MS when conditioned on the presence (OR = 1.67, 95% CI = 1.19-2.37, P = 1.9 x 10(-3)) and absence (OR = 1.49, 95% CI = 1.15-1.95, P = 2.3 x 10(-3)) of CLEC16A rs6498169*G, a putative MS risk allele adjacent to CIITA.
|
20211854 |
2010 |
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
LHGDN |
The expanding genetic overlap between multiple sclerosis and type I diabetes.
|
18987646 |
2009 |
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
For example, nucleotide variation in the interleukin 7 receptor (IL7RA), the interleukin 2 receptor (IL2RA), the CD58 and the c-type lectin domain family 16 member A (CLEC16A) genes has been consistently associated with MS in several populations.
|
20450971 |
2010 |
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Taken together these data provide evidence of joint disease association in T1D and MS within CLEC16A and underline a shared disease pathway.
|
18946483 |
2009 |
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Multiple sclerosis (MS) shares some risk genes with other disorders hallmarked by an autoimmune pathogenesis, most notably IL2RA and CLEC16A.
|
22130326 |
2012 |
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
To dissect further the involvement of four recent identified MS susceptibility genes (KIAA0350, IL2RA, RPL5 and CD58) in disease pathogenesis, we genotyped 94 haplotype-tagging single nucleotide polymorphisms (SNPs) from these loci in 1146 MS cases and 1309 controls.
|
19375175 |
2009 |
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Associations of CLEC16A*G/G and both biallelic combinations in women with MS survived the permutation test.
|
25903733 |
2015 |
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
In reciprocal experiments, a 20 kb fragment of intron 19 of CLEC16A, containing SNPs associated with T1D and MS, as well as with DEXI expression, interacted with the promotor region of DEXI but not with candidate DNA fragments containing other potential causal genes in the region, including CLEC16A.
|
21989056 |
2012 |
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
CTD_human |
Taken together these data provide evidence of joint disease association in T1D and MS within CLEC16A and underline a shared disease pathway.
|
18946483 |
2009 |
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
To explore the CLEC16A association in MS in more detail, we genotyped 57 SNPs in 807 Norwegian MS patients and 1027 Norwegian controls.
|
21179112 |
2011 |
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
CTD_human |
We also replicated several known MS associations (HLA-DR15, P = 7.0 x 10(-184); CD58, P = 9.6 x 10(-8); EVI5-RPL5, P = 2.5 x 10(-6); IL2RA, P = 7.4 x 10(-6); CLEC16A, P = 1.1 x 10(-4); IL7R, P = 1.3 x 10(-3); TYK2, P = 3.5 x 10(-3)) and observed a statistical interaction between SNPs in EVI5-RPL5 and HLA-DR15 (P = 0.001).
|
19525955 |
2009 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
CLEC16A is in a locus genetically linked to autoimmune diseases including multiple sclerosis, but the function of this gene in the nervous system is unknown.
|
26987296 |
2016 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Multiple sclerosis-associated single-nucleotide polymorphisms in CLEC16A correlate with reduced SOCS1 and DEXI expression in the thymus.
|
23151489 |
2013 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
HLA-DRB1*11 and *15, IL7RA rs6897932*C/C, CXCR5 rs523604*A/A, and CLEC16A rs6498169*G/G were found as MS-associated variants common for PPMS and RRMS.
|
30711878 |
2019 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
|
19525953 |
2009 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Independent genome-wide association studies highlighted the function of CLEC16A/KIAA0350 polymorphisms modifying the risk to either multiple sclerosis (rs6498169) or type 1 diabetes (rs2903692).
|
19337309 |
2009 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation.
|
27386562 |
2016 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
|
19525953 |
2009 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
21833088 |
2011 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
CLEC16A, a putative immunoreceptor, was recently established as a susceptibility locus for type I diabetes and multiple sclerosis.
|
20220768 |
2010 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Of the 17 IMSGC SNPs, five SNPs showed genome-wide significant association with MS: HLA-DRA (P=8E-124), IL7R (P=6E-09), IL2RA (P=1E-11), CD58 (P=4E-09) and CLEC16A (P=3E-12).
|
19834503 |
2009 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Associations of CLEC16A polymorphisms with T1D and MS were successfully replicated in a Spanish population.
|
19221398 |
2010 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Taken together these data provide evidence of joint disease association in T1D and MS within CLEC16A and underline a shared disease pathway.
|
18946483 |
2009 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
21833088 |
2011 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We find that the previously investigated single-nucleotide polymorphism rs4774 is associated with MS risk in cases carrying the HLA-DRB1*15 allele (P=0.01, odds ratio (OR): 1.21, 95% confidence interval (CI): 1.04-1.40) or the HLA-A*02 allele (P=0.01, OR: 1.33, 95% CI: 1.07-1.64) and that these associations are independent of the adjacent confirmed MS susceptibility gene CLEC16A.
|
24430172 |
2014 |